Experience shapes the brain's circuitry throughout adulthood

The adult brain, long considered to be fixed in its wiring, is in fact remarkably dynamic. Neuroscientists once thought that the brain's wiring was fixed early in life, during a critical period beyond which changes were impossible. Recent discoveries have challenged that view, and now, research by scientists at Rockefeller University suggests that circuits in the adult brain are continually modified by experience. The researchers, led by Charles D. Gilbert, Arthur and Janet Ross Professor and head of the Laboratory of Neurobiology, observed how neurons responsible for receiving input from a mouse's whiskers shift their relationships with one another after single whiskers are removed. The experiments explain how the circuitry of a region of the mouse brain called the somatosensory cortex, which processes input from the various systems in the body that respond to the sense of touch, can change. The findings will be published next week in the online, open access journal PLoS Biology.

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